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Hypodontia - dysplasia of nails
1 OMIM reference -
1 associated gene
14 signs/symptoms
PROTEIN INTERACTIONS: 1
B-cell chronic lymphocytic leukemia
6 OMIM references -
7 associated genes
No signs/symptoms info
Hypodontia - dysplasia of nails
B-cell chronic lymphocytic leukemia

MSX1
(UniProt - OMIM)
 ARL11
(UniProt - OMIM)
ATM
(UniProt - OMIM)
CCND1
(UniProt - OMIM)
IGHG1
(UniProt - OMIM)
IGHV3-21
()
POT1
(UniProt - OMIM)
TP53
(UniProt - OMIM)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
MSX1
(0.65)
TP53


Citations in the biomedical literature:


Hypodontia - dysplasia of nails
MSX1
B-cell chronic lymphocytic leukemia
ARL11 ATM CCND1 IGHG1 IGHV3-21 POT1
TP53



Hypodontia - dysplasia of nails
B-cell chronic lymphocytic leukemia

Synonym(s):
- Hypodontia - nail dysgenesis
- Tooth and nail syndrome
- Witkop syndrome
Synonym(s):
- B-CLL
- B-cell chronic lymphoid leukemia
- Lymphoplasmacytic leukemia
- Lymphoplasmacytoid immunocytoma
- Small lymphocytic lymphoma
Classification (Orphanet):
- Rare developmental defect during embryogenesis
- Rare genetic disease
- Rare odontologic disease
- Rare skin disease
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Classification (ICD10):
- Neoplasms -
Epidemiological data:
Class of prevalence: unknown
Average age onset: childhood
Average age of death: normal
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adulthood
Average age of death: -
Type of inheritance: sporadic
External references:
1 OMIM reference -
No MeSH references
External references:
6 OMIM references -
1 MeSH reference: D015451
Hypodontia - dysplasia of nails

Very frequent
- Absent / small fingernails / anonychia of hands
- Absent / small toenails / anonychia of feet
- Anodontia / oligodontia / hypodontia
- Anomalies of teeth and dentition
- Autosomal dominant inheritance
- Delayed dentition / eruption of teeth / lack of eruption of teeth
- Dysplastic / thick / grooved fingernails
- Dysplastic / thick / grooved toenails
- Nails anomalies
- Thin / hypoplastic toenails
- Tooth shape anomaly

Frequent
- Everted lower lip
- Fine hair

Occasional
- Abnormal / polycystic ovaries


B-cell chronic lymphocytic leukemia

(no data available)